Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination
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چکیده
منابع مشابه
Deficits in motor coordination with aberrant cerebellar development in mice lacking testicular orphan nuclear receptor 4.
Since testicular orphan nuclear receptor 4 (TR4) was cloned, its physiological function has remained largely unknown. Throughout postnatal development, TR4-knockout (TR4-/-) mice exhibited behavioral deficits in motor coordination, suggesting impaired cerebellar function. Histological examination of the postnatal TR4-/- cerebellum revealed gross abnormalities in foliation; specifically, lobule ...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2015
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2014.12.013